Molecular Characterization of Borrelia burgdorferi erp Promoter/Operator Elements
نویسندگان
چکیده
منابع مشابه
Molecular characterization of Borrelia burgdorferi erp promoter/operator elements.
Many Borrelia burgdorferi Erp outer surface proteins have been demonstrated to bind the host complement regulator factor H, which likely contributes to the ability of these organisms to evade the host innate immune system. B. burgdorferi controls Erp protein synthesis throughout the bacterial infectious cycle, producing the proteins during mammalian infections but repressing their synthesis dur...
متن کاملSimultaneous coexpression of Borrelia burgdorferi Erp proteins occurs through a specific, erp locus-directed regulatory mechanism.
An individual Borrelia burgdorferi bacterium can encode as many as 13 different Erp (OspE/F-related) proteins from mono-and bicistronic loci that are carried on up to 10 separate plasmids. We demonstrate through multilabel immunofluorescence analyses that individual bacteria simultaneously coexpress their entire Erp protein repertoire. While it has been proposed that B. burgdorferi controls exp...
متن کاملMolecular Characterization of Borrelia burgdorferi from Case of Autochthonous Lyme Arthritis
Miguel Delibes-Mateos, Catarina Ferreira, Francisco Carro, Marco A. Escudero, and Christian Gortázar Author affiliations: Instituto de Investigación en Recursos Cinegéticos, a collaborative agency of the Consejo Superior de Investigaciones Científicas, Universidad de Castilla-La Mancha, and Junta de Comunidades de Castilla-La Mancha, Ciudad Real, Spain (M. Delibes-Mateos, C. Gortázar); Trent Un...
متن کاملGenetics of Borrelia burgdorferi.
The spirochetes in the Borrelia burgdorferi sensu lato genospecies group cycle in nature between tick vectors and vertebrate hosts. The current assemblage of B. burgdorferi sensu lato, of which three species cause Lyme disease in humans, originated from a rapid species radiation that occurred near the origin of the clade. All of these species share a unique genome structure that is highly segme...
متن کاملMolecular and evolutionary characterization of the cp32/18 family of supercoiled plasmids in Borrelia burgdorferi 297.
In this study, we characterized seven members of the cp32/18 family of supercoiled plasmids in Borrelia burgdorferi 297. Complete sequence analysis of a 21-kb plasmid (cp18-2) confirmed that the strain 297 plasmids are similar in overall content and organization to their B31 counterparts. Of the 31 open reading frames (ORFs) in cp18-2, only three showed sequence relatedness to proteins with kno...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 2004
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.186.9.2745-2756.2004